Thrombotic thrombocytopenic purpura by widad darwish on prezi. We describe a case of cttp first diagnosed at age 70 years in a female presenting with an acute ischaemic stroke and thrombocytopenia, in whom a disintegrin and. Congenital thrombotic thrombocytopenic purpura presenting. Ppt thrombotic%20thrombocytopenic%20purpura powerpoint. Thrombotic thrombocytopenic purpura epilepsy foundation. Thrombotic microangiopathy tma, a pathologic description, is characterized by a clinical presentation with thrombocytopenia, microangiopathic hemolytic anemia maha, and organ injury 1,2. New insights in pathogenesis and treatment modalities speakers. George university of oklahoma medicine grand rounds washington university january 18, 2010 a free powerpoint ppt presentation displayed as a flash slide show on id. Thrombotic thrombocytopenic purpura national heart, lung. Thrombotic thrombocytopenic purpura authorstream presentation. Thrombotic thrombocytopenic purpura ttp is an unusual disease manifested clinically by hemolytic anemia, thrombocytopenia, fever, renal involvement and neurologic manifestations, and characterized pathologically by occlusion of small blood vessels in many organs by an homogenous, eosinophilic matter. Peripheral smear showing microangiopathic hemolytic features with numerous rbc fragments helmet cellsschistocytes.
Wecome to the official fb page of the ttp association. Thrombotic thrombocytopenic purpura powerpoint ppt presentation. History ttp epidemiology causes the incidence of ttp is about 35 cases per million people per year. In this disease, tiny clots form throughout your body. Thrombotic thrombocytopenic purpura association home. February 16, 1995 purpose the objectives of this initiative are to 1 support studies on the. This is because platelets are being destroyed by the immune system. Thrombotic microangiopathy is a general term for the combination of microangiopathic hemolytic anemia and thrombocytopenia, often accompanied by signs and symptoms consistent with disseminated microvascular thrombosis. Thrombotic thrombocytopenic purpura ttp presentation transcript. The clots can limit or block the flow of oxygenrich blood to the bodys organs, such as the brain, kidneys, and heart.
We performed a retrospective cohort study of 178 consecutively treated patients. Without enough platelets, you can bleed in your organs, underneath your skin, or from the surface of your skin. Thrombotic thrombocytopenic purpura ttp is a rare blood disorder. Find powerpoint presentations and slides using the power of, find free presentations research about thrombotic thrombocytopenic purpura ppt. Thrombotic thrombocytopenic purpura ppt xpowerpoint. It is characterized by smallvessel plateletrich thrombi that cause thrombocytopenia, microangiopathic hemolytic anemia, and sometimes organ damage. Thrombotic thrombocytopenic purpura is a rare disorder that causes blood clots thrombi to form in small blood vessels throughout the body. Thrombotic thrombocytopenic purpura ttp ppt video online. Idiopathic ttp occurs more often in women and blackafrican american people. In fact, hus and ttp were suggested to be varying manifestations of a single disease. Ppt thrombotic thrombocytopenic purpura powerpoint.
To download the powerpoint slides of this presentation, join the isth. It can manifest in a diverse range of conditions and presentations, but aki is a common prominent feature because of the apparent propensity of the glomerular circulation to. Ppt thrombotic thrombocytopenic purpura a disorder of vwf. Thrombotic thrombocytopenic purpura linkedin slideshare. With treatment, the chance of remission a symptomfree period is good. Expert statements on the standard of care in critically. Thrombotic thrombocytopenic purpura national library of. Large vessel stroke as initial presentation of thrombotic. Peripheral blood smear from a patient with a microangiopathic hemolytic anemia with marked red cell fragmentation.
Ttp causes blood clots thrombi to form in small blood vessels throughout the body. Several other syndromes including haemolytic uraemic. Thrombotic thrombocytopenic purpura was diagnosed with adamts a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member activity of ttp. The disorder is characterized by thrombocytopenia, hemolytic anemia due to red cell fragmentation, and a combination of clinical findings, including cns dysfunction, fever, and renal failure. Thrombotic thrombocytopenic purpura ttp powerpoint ppt presentation. Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome ttphus are related and uncommon disorders with a high fatality and complication rate if untreated. In ttp, blood clots form in small blood vessels throughout the body the clots can limit or block the flow of oxygenrich blood to the bodys organs, such as the brain, kidneys, and heart. View and download powerpoint presentations on thrombotic thrombocytopenic purpura ppt. In ttp, blood clots form in small blood vessels throughout the body. Formation and resolution of pial microvascular thrombosis. Laboratory studies for suspected ttp include a cbc, platelet count, blood smears, coagulation. Thrombotic thrombocytopenic purpura ttp, acquired is a blood disorder characterized by low platelets i.
Microvascular thrombosis in the brain is the hallmark pathology of thrombotic thrombocytopenic purpura. The report identifies that in france, twothirds of patients with thrombotic thrombocytopenic purpura are women, the median age at presentation is 43 years, and a prevalence of cases of thrombotic thrombocytopenic purpura per million people is reported. Thrombotic thrombocytopenic purpura ttp was first described by moschowitz in 1924. Plasma exchange therapy has been shown to produce high response rates and improve survival in patients with many forms of ttphus. Symptoms may include bruising, nosebleed or bleeding in the mouth, bleeding into the skin, and abnormally heavy menstruation. Ttp hus thrombotic thrombocytopenic purpura atypical hus pathology physiology. Ppt thrombotic thrombocytopenic purpura ttp powerpoint. Thrombotic thrombocytopenic purpurahemolytic uremic. Blood diseases aids pathogenesis national heart, lung, and blood institute letter of intent receipt date. The laboratory and clinical manifestations are the results of microvascular thrombotic lesions, which. Symptoms may include large bruises, fever, weakness, shortness of breath, confusion, and headache. Thrombotic thrombocytopenic purpura lecture you have to purchase the course pance blueprint. This is the first national ttp foundation in the u.
Thrombotic thrombocytopenic purpura ttp is an uncommon disease with an incidence of approximately four cases per million adults per year. Thrombotic thrombocytopenia purpura hematology blueprint. Thrombotic thrombocytopenic purpura, acquired genetic. Thrombotic thrombocytopenic purpura a community perspective james n. Thrombotic thrombocytopenic purpura ttp is an uncommon but serious disorder of young adults. Ppt thrombotic thrombocytopenic purpura a disorder of vwf proteolysis powerpoint presentation free to view id. Patients with thrombotic thrombocytopenic purpura ttp and other thrombotic microangiopathies typically exhibit schistocytes, thrombocytopenia, and organ injury secondary to arteriole and capillary thrombosis. Full text hl95007 thrombotic thrombocytopenic purpura and hiv nih guide, volume 23, number 36, october 14, 1994 rfa. Ttphus still can be seen in medical records and even in medical journals today although, thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome are now known as 2 distinct diseases. A free powerpoint ppt presentation displayed as a flash slide show on id. Similarity in clinical presentation may hinder diagnosis and optimal treatment selection in the urgent setting in the icu.
Thrombotic thrombocytopenic purpura blood american. Thrombotic thrombocytopenic purpura ttp refers to thrombotic microangiopathy, without an obvious predisposing condition, and without oliguric renal. These clots can cause serious medical problems if they block vessels and. Idiopathic thrombocytopenic purpura itp is a bleeding disorder characterized by too few platelets in the blood.
This results in a low platelet count, low red blood cells due to their breakdown, and often kidneys, heart, and brain dysfunction. A typical hemolytic uremic syndrome ahus presents similarly to thrombotic thrombocytopenic purpura ttp and other causes or conditions with thrombotic microangiopathy tma, such as disseminated intravascular coagulation or sepsis. Current understanding of the pathophysiology of thrombotic. Idiopathic autoimmune thrombocytopenic purpuraitp the most common cause of acute onset of thrombocytopenia in an otherwise well child estimated about 1 in 20,000 children a recent history of viral illness is described in 5065% of cases of childhood itp 1252015 idiopathic thrombocytopenic purpura prof. Eli moschcowitz described a 16 year old girl with abrupt onset of petechiae, pallor, followed by paralysis, coma, and death. Thrombotic thrombocytopenic purpura what you need to know. Purpura and fat rn fever, anemia, thrombocytopenia, renal failure, neurological symptoms. Thrombotic microangiopathy and the kidney american. Autopsy showed hyaline thrombi occluding terminal arterioles and capillaries. Ttp results from inherited deficiency or acquired inhibition of the enzyme. These clots can cause serious medical problems if they block vessels and restrict blood flow to organs such as the brain, kidneys, and heart. Thrombotic thrombocytopenic purpura a community perspective. Idiopathic thrombocytopenic purpura genetic and rare.
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